Duzallo tablets should be taken in the morning with food and water. Patients should be instructed to stay well hydrated. Adverse effects associated with the use of Duzallo may include, but are not limited to, the following:. Lesinurad reduces serum uric acid levels by inhibiting the function of transporter proteins involved in uric acid reabsorption in the kidney.
Allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation.
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Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid, the end product of purine metabolism in humans. Allopurinol is metabolized to the corresponding xanthine analogue, oxypurinol alloxanthine , which also is an inhibitor of xanthine oxidase. It is also used in the treatment of leishmaniasis in dogs and cats and is usually combined with other drugs. Many drugs are commonly prescribed for off label use in veterinary medicine.
Allopurinol comes in tablet form and is given orally by mouth. It may be given with or without food. If your pet vomits or acts sick after receiving the drug on an empty stomach try giving the next dose with a small amount of food. If vomiting continues, contact your veterinarian. Compounded liquid forms may be prepared by your veterinarian. The liquid form must be measured carefully.
Your veterinarian can provide you with a syringe to help measure the correct amount. This medication can take up to a few weeks before effects are noted, and at times improvement may not be visibly obvious. If you miss giving your pet a dose, give the next dose as soon as you remember, but if it is close to the next scheduled dose when you remember, skip the missed dose and give it at the next scheduled time.
Never give your pet two doses at once or give extra doses.
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Side effects of allopurinol are uncommon in dogs and cats. Some animals may vomit after receiving the medication. When used for the long-term prevention of stones in dogs, a low-purine diet should be fed. In dogs receiving higher doses of allopurinol, certain types of bladder stones xanthine stones may develop.
Any side effects that you observe should be reported to your veterinarian.
This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease. Allopurinol should be used with caution in animals that have liver or kidney problems. The safety of this medication has not been determined in breeding or pregnant animals. It should be used with caution in nursing dogs.
Caution must be taken when allopurinol is used in conjunction with certain antibiotics e. Be sure to tell your veterinarian about any medications including vitamins, supplements, or herbal therapies that your pet is taking. Monitoring of the levels of uric acid in the blood and urine may be recommended by your veterinarian. Liver and kidney function tests may also be recommended. If allopurinol is being used to treat leishmaniasis, your veterinarian will monitoring the clinical signs of the disease.
Because there is the possibility for bladder stones to develop with long-term use, dogs should also be monitored for urinary signs straining to urinate, blood in the urine, pain while taking allopurinol and taken to your veterinarian if any of these signs occur. Store allopurinol in a tightly sealed container at room temperature. Your reactions could be impaired. This is not a complete list of side effects and others may occur.
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Call your doctor for medical advice about side effects. Allopurinol side effects in more detail. This list is not complete. Other drugs may interact with allopurinol, including prescription and over-the-counter medicines, vitamins , and herbal products.
Not all possible drug interactions are listed here. Allopurinol drug interactions in more detail. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use allopurinol only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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See also: Allopurinol drug interactions in more detail. Drug Status Rx. Availability Prescription only.
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